کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368478 1218793 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary TWEAK and the activity of lupus nephritis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Urinary TWEAK and the activity of lupus nephritis
چکیده انگلیسی

The TNF superfamily cytokine TWEAK induces mesangial cells, podocytes, and endothelial cells to secrete pro-inflammatory chemokines including MCP-1, IP-10 and RANTES, which are crucial in the pathogenesis of lupus nephritis (LN). As TWEAK regulates the secretion of these inflammatory mediators, we studied whether urinary TWEAK (uTWEAK) levels might be predictive and/or diagnostic in LN.In a cross-sectional study of a large, multi-center cohort of systemic lupus erythematosus (SLE) patients, uTWEAK levels were higher in patients with active as compared to never or non-active nephritis (median (IQR): 16.3 (9.9–23.0) versus 5.5 (2.3–16.8) pg/mg creatinine, p = 0.001), and levels of uTWEAK correlated with the renal SLE disease activity index (rSLEDAI) score (r = 0.405, p < 0.001). uTWEAK levels were higher in patients undergoing a flare as compared to patients with chronic stable disease (11.1 (8.1–18.2) and 5.2 (2.3–15.3) pg/mg creatinine, respectively; p = 0.036). Moreover, uTWEAK levels were significantly higher in patients undergoing a renal flare, as opposed to a non-renal flare (12.4 (9.1–18.2) and 5.2 (3.0–11.9) pg/mg creatinine, respectively; p = 0.029).An accurate, non-invasive method to repeatedly assess kidney disease in lupus would be very helpful in managing these often challenging patients. Our study indicates that urinary TWEAK levels may be useful as a novel biomarker in LN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 27, Issue 4, December 2006, Pages 242–250
نویسندگان
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