کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3368501 | 1592316 | 2007 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: OBF-1 is essential for the generation of antibody-secreting cells and the development of autoimmunity in MRL-lpr mice OBF-1 is essential for the generation of antibody-secreting cells and the development of autoimmunity in MRL-lpr mice](/preview/png/3368501.png)
As reported previously, the lack of the transcriptional co-activator OBF-1 prevented development of autoimmunity in Aiolos knockout mice. To further investigate the role and mechanism of OBF-1 in autoimmunity, we crossed OBF-1 null mice with MRL-lpr mice and generated OBF-1-deficent MRL-lpr mice. OBF-1 deletion abrogated all autoantibodies in the MRL-lpr mice, including anti-dsDNA Ab and anti-Sm Ab. The failure to produce autoantibodies was not related to development of immature or mature B cells, but correlated with severely reduced antibody-secreting cells (ASCs). The loss of OBF-1 protected against hypergammaglobulinemia, immune complex deposition, glomerulonephritis, and early mortality in MRL-lpr mice. In addition, accumulation of CD4−CD8−B220+CD3+ T cells that characteristically develop in Fas mutation mice were markedly reduced in MRL-lpr mice without OBF-1. These results identify OBF-1 as a critical gene in the development of autoantibodies and reveal an essential role for OBF-1 in the generation of antibody/autoantibody-secreting cells in vivo.
Journal: Journal of Autoimmunity - Volume 29, Issues 2–3, September–November 2007, Pages 87–96