کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3369119 | 1219012 | 2011 | 8 صفحه PDF | دانلود رایگان |

BackgroundPathogenesis of human herpesvirus 6 (HHV-6) encephalitis, in particular difference between HHV-6 encephalitis at the time of primary infection and reactivation remains unclear.ObjectivesTo elucidate the mechanism of HHV-6 encephalitis at the time of primary infection and reactivation.Study designTwenty-two HHV-6 encephalitis patients at the time of primary infection, 6 febrile convulsion (FC) patients caused by HHV-6 infection, and 14 FC patients without HHV-6 infection (non HHV-6 FC) were enrolled. Additionally, 7 stem cell transplant recipients with HHV-6 encephalitis and eight adult controls were also enrolled in this study. Cerebrospinal fluid (CSF) HHV-6 DNA copy numbers and biomarkers levels were compared.ResultsLow copy number of CSF HHV-6 DNA was detected in 7 of the 22 patients with HHV-6 encephalitis in primary infection, whereas all seven CSF samples collected from post-transplant HHV-6 encephalitis patients contained high viral DNA copy numbers (P < 0.001). CSF concentrations of IL-6 (P = 0.032), IL-8 (P = 0.014), MMP-9 (P = 0.004), and TIMP-1 (P = 0.002) were significantly higher in patients with HHV-6 encephalitis in primary infection than non-HHV-6 FC. CSF IL-6 (P = 0.008), IL-8 (P = 0.015), and IL-10 (P = 0.019) concentrations were significantly higher in patients with post-transplant HHV-6 encephalitis than adult controls.ConclusionThe present study suggests that the characteristics of HHV-6 encephalitis are different between HHV-6 encephalitis at the time of primary infection and reactivation in transplant recipients.
Journal: Journal of Clinical Virology - Volume 51, Issue 1, May 2011, Pages 12–19