کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3369883 1219057 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis
چکیده انگلیسی

BackgroundDiverticulitis affects 10% of the western population and is characterized by microscopic inflammation of the colon. Increasing evidence suggests that human cytomegalovirus (HCMV) is an important pathogen in various inflammatory diseases. We hypothesized that HCMV contributes to the progression of diverticulitis, especially in immunocompromised patients in whom HCMV is a significant pathogen.ObjectivesTo determine if HCMV is associated with diverticulitis and with an increased frequency of diverticulitis complications.Study designWe examined the prevalence of an active HCMV infection in 23 patients with diverticulitis. Serum samples were analyzed for the presence of HCMV-IgG and HCMV-IgM antibodies in 11 of these patients. Immunohistochemistry was used for detection of HCMV early antigens in intestinal paraffin tissue sections obtained from the diverticulitis patients.ResultsHCMV-early proteins could be detected in intestinal cells in 16/23 (69.6%) patients with diverticulitis. All of the 11 patients with serum samples were HCMV-IgG positive and 2 of these were also HCMV-IgM positive.ConclusionActive HCMV infection is frequently associated with diverticulitis and could contribute to the inflammatory process characteristic of diverticulitis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 40, Issue 2, October 2007, Pages 116–119
نویسندگان
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