کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
338950 | 548009 | 2006 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population No association of complexin1 and complexin2 genes with schizophrenia in a Japanese population](/preview/png/338950.png)
Several investigations suggest that complexin may be a schizophrenia-susceptibility factor. We conducted a genetic association analysis between complexin genes (CPLX1 and CPLX2) and schizophrenia in Japanese patients (377 cases and 341 controls). Ten and eleven haplotype-tagging (ht)SNPs in CPLX1 and CPLX2, respectively, were selected. Only one htSNP (rs930047 in CPLX2) in allele-wise analysis showed significance, and even this disappeared with an increased sample size (563 cases and 519 controls: P = .757). Haplotype-wise analysis showed a weak association with a combination of htSNPs in CPLX2 (P = .0424), but this may be a result of type I error due to multiple testing. Our results suggest that complexin genes do not play a major role in schizophrenia in Japanese patients.
Journal: Schizophrenia Research - Volume 82, Issues 2–3, 28 February 2006, Pages 185–189