کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391380 1221040 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generation
چکیده انگلیسی

Within the lymphocyte lineages, restriction of immunoglobulin V(D)J recombination to B cells and T cell receptor (TCR) recombination to T cells is governed by a myriad of epigenetic mechanisms that control the chromatin accessibility of these loci to the Rag recombinase machinery in a lineage and developmental stage-specific manner. These mechanisms operate both locally at individual gene segments, and globally over large chromatin domains in these enormous multigene loci. In this review we will explore the established and emerging roles of three aspects of epigenetic regulation that contribute to large-scale control of the immunoglobulin heavy chain locus in B cells: non-coding RNA transcription, regulatory elements, and nuclear organization. Recent conceptual and technological advances have produced a paradigm shift in our thinking about how these components regulate gene expression in general and V(D)J recombination in particular.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 22, Issue 6, December 2010, Pages 353–361
نویسندگان
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