کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3391410 | 1221045 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular mechanisms of allorecognition in a basal chordate
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Allorecognition has been described in many metazoan phyla, from the sponges to the mammals. In vertebrates, allorecognition is a result of a MHC-based recognition event central to adaptive immunity. However, the origin of the adaptive immune system and the potential relationship to more primitive allorecognition systems is unclear. The colonial ascidian, Botryllus schlosseri, has been used as a model organism for the study of allorecognition for over a century, as it undergoes a natural transplantation reaction controlled by a single, highly polymorphic locus. Herein we will summarize our current understanding of the molecular mechanisms that underlie this innate allorecognition reaction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 22, Issue 1, February 2010, Pages 34–38
Journal: Seminars in Immunology - Volume 22, Issue 1, February 2010, Pages 34–38
نویسندگان
Tanya R. McKitrick, Anthony W. De Tomaso,