کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3391473 | 1221051 | 2011 | 10 صفحه PDF | دانلود رایگان |
The thymus is seeded by bone marrow-derived progenitors, which undergo a series of differentiation and proliferation events in order to generate functional T lymphocytes. The Notch signaling pathway, together with multiple transcription factors, act in concert to commit progenitors to a T-lineage fate, extinguishing non-T cell potential, inducing thymocyte differentiation and supporting proliferation and survival along the way to becoming a mature T cell. This review focuses on recent evidence regarding the complex interplay between the Notch pathway and other key transcription factors at specific lineage-decision points during the program of T cell development.
► This review highlights several important lineage commitment events that take place during intrathymic T cell development.
► The critical role of Notch signaling in initiating T-lineage commitment is discussed.
► The complex interplay between Notch and other key transcription factors is discussed.
Journal: Seminars in Immunology - Volume 23, Issue 5, October 2011, Pages 350–359