کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391498 1221053 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A fresh look at the hygiene hypothesis: How intestinal microbial exposure drives immune effector responses in atopic disease
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A fresh look at the hygiene hypothesis: How intestinal microbial exposure drives immune effector responses in atopic disease
چکیده انگلیسی

There currently is no consensus on which immunological mechanisms can best explain the rise in atopic disease post industrialization. The hygiene hypothesis lays groundwork for our understanding of how altered microbial exposures can drive atopy; yet since its introduction increasing evidence suggests the exposure of our immune system to the intestinal microbiota plays a key role in development of atopic disease. As societal change shifts our microbial exposure, concordant shifts in the tolerant and effector functions of our immune systems give rise to more hypersensitive responses to external antigens. This is contrasted with the greater immune tolerant capabilities of individuals still living in regions with lifestyles more representative of our evolutionary history. Recent findings, buoyed by technological advances in the field, suggest a direct role for the intestinal microbiota-immune system interplay in the development of atopic disease mechanisms. Overall, harnessing current mechanistic studies for translational research into microbiota composition and function in relation to atopy have potential for the design of therapeutics that could moderate these diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 25, Issue 5, 30 November 2013, Pages 378–387
نویسندگان
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