کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391573 1221061 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular and cellular basis of T cell lineage commitment
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Molecular and cellular basis of T cell lineage commitment
چکیده انگلیسی

The thymus forms as an alymphoid thymic primordium with T cell differentiation requiring the seeding of this anlage. This review will focus on the characteristics of the hematopoietic progenitors which colonize the thymus and their subsequent commitment/differentiation, both in mice and men. Within the thymus, the interplay between Notch1 and IL-7 signals is crucial for the orchestration of T cell development, but the precise requirements for these factors in murine and human thympoeisis are not synonymous. Recent advances in our understanding of the mechanisms regulating precursor entry and their maintenance in the thymus will also be presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 22, Issue 5, October 2010, Pages 270–275
نویسندگان
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