کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391603 1221063 2010 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice
چکیده انگلیسی

While insights into the molecular processes that specify adoption of the αβ and γδ fates are beginning to emerge, the basis for control of specification remains highly controversial. This review highlights the current models attempting to explain T lineage commitment. Recent observations support the hypothesis that the T cell receptor (TCR) provides instructive cues through differences in TCR signaling intensity and/or longevity. Accordingly, we review evidence addressing the importance of differences in signal strength/longevity, how signals differing in intensity/longevity may be generated, and finally how such signals modulate the activity of downstream effectors to promote the opposing developmental fates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 22, Issue 4, August 2010, Pages 237–246
نویسندگان
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