کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391646 1221067 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasmacytoid dendritic cells in the skin: To sense or not to sense nucleic acids
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Plasmacytoid dendritic cells in the skin: To sense or not to sense nucleic acids
چکیده انگلیسی

Plasmacytoid dendritic cells (pDCs) are specialized sensors of viral nucleic acids that initiate protective immunity through the production of type I interferons (IFNs). Normally, pDCs fail to sense host-derived self-nucleic acids but do so when self-nucleic acids form complexes with endogenous antimicrobial peptides produced in damaged skin. Whereas regulated expression of antimicrobial peptides may lead to pDC activation and protective immune responses to skin injury, overexpression of antimicrobial peptides in psoriasis drives excessive sensing of self-nucleic acids by pDCs resulting in IFN-driven autoimmunity. In skin tumors, pDCs are unable to sense self-nucleic acids; however, therapeutic activation of pDCs by synthetic nucleic acids or analogues can be exploited to generate antitumor immunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 21, Issue 3, June 2009, Pages 101–109
نویسندگان
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