کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391670 1221069 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biochemical signaling pathways for memory T cell recall
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Biochemical signaling pathways for memory T cell recall
چکیده انگلیسی

Memory T cells exhibit low activation thresholds and rapid effector responses following antigen stimulation, contrasting naive T cells with high activation thresholds and no effector responses. Signaling mechanisms for the distinct properties of naive and memory T cells remain poorly understood. Here, I will discuss new results on signal transduction in naive and memory T cells that suggest proximal control of activation threshold and a distinct biochemical pathway to rapid recall. The signaling and transcriptional pathways controlling immediate effector function in memory T cells closely resemble pathways for rapid effector cytokine production in innate immune cells, suggesting memory T cells use innate pathways for efficacious responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 21, Issue 2, April 2009, Pages 84–91
نویسندگان
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