کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3391698 | 1221072 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 20, Issue 3, June 2008, Pages 159–163
Journal: Seminars in Immunology - Volume 20, Issue 3, June 2008, Pages 159–163
نویسندگان
Peter Lane, Mi-Yeon Kim, David Withers, Fabrina Gaspal, Vasileios Bekiaris, Guillaume Desanti, Mahmood Khan, Fiona McConnell, Graham Anderson,