کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391706 1221073 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polyspecificity of T cell and B cell receptor recognition
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Polyspecificity of T cell and B cell receptor recognition
چکیده انگلیسی

A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this discovery for lymphocyte biology. The workshop recommends general use of the term polyspecificity because it emphasizes two fundamental aspects, the inherent specificity of receptor recognition and the ability to recognize multiple ligands. Many different examples of polyspecificity and the structural mechanisms were discussed, and the group concluded that polyspecificity is a general, inherent feature of TCR and antibody recognition. This review summarizes the relevance of polyspecificity for lymphocyte development, activation and disease processes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 19, Issue 4, August 2007, Pages 216–224
نویسندگان
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