Synthetic surfaces as artificial antigen presenting cells in the study of T cell receptor triggering and immunological synapse formation

T cell activation occurs when T cell receptors engage peptide-major histocompatibility complex (pMHC) molecules displayed on the surface of antigen presenting cells (APCs). Clustering of TCRs and other receptors in physical patterns at the T–APC interface forms a structure known as an immunological synapse (IS). Studies of the IS are challenging due to the cell–cell contact context of the governing interactions. Model surfaces as synthetic APCs have thus been developed, where the type, quantity, and physical arrangement of ligands displayed to T cells are precisely controlled. These model systems have provided important insights into the structure and function of the IS.