کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
339171 548051 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The MDGA1 gene confers risk to schizophrenia and bipolar disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The MDGA1 gene confers risk to schizophrenia and bipolar disorder
چکیده انگلیسی

ObjectiveThe structural, cytoarchitectural and functional brain abnormalities reported in patients with mental disorders may be due to aberrant neuronal migration influenced by cell adhesion molecules. MDGA1, like Ig-containing cell adhesion molecules, has several cell adhesion molecule-like domains. Moreover, Kahler et al. (2008) reported that the MDGA1 gene was a schizophrenia susceptibility gene in Scandinavian population. To further investigate whether the MDGA1 gene is a shared risk factor of schizophrenia, bipolar disorder and major depressive disorder in Chinese Han population, we conducted this study.MethodsWe recruited 1135 unrelated schizophrenia patients, 1135 unrelated bipolar disorder patients, 1135 unrelated major depressive disorder patients and 1135 unrelated controls of Chinese Han origin. A total of eleven common SNPs were genotyped using TaqMan® technology.ResultsThe genotype frequency of rs11759115 differed significantly between schizophrenia patients and controls. The C-C haplotype of rs11759115-rs7769372 was also positively associated with schizophrenia (permutated p = 0.046). Rs1883901 was found to be positively associated with bipolar disorder (allele: permutated p = 0.0085; genotype: permutated p = 0.0009; OR = 1.31 [95%CI = 1.12–1.52]). The A-G-G haplotype of rs1883901-rs10807187-rs9462343 was also positively associated with bipolar disorder with a global p value of 0.0391 after permutations. No individual SNP or haplotype was associated with major depressive disorder after permutations.ConclusionThe MDGA1 gene may confer risk to schizophrenia and bipolar disorder in Chinese Han population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 125, Issues 2–3, February 2011, Pages 194–200
نویسندگان
, , , , , , , , , , , ,