کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391711 1221073 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TCR recognition of peptide/MHC class II complexes and superantigens
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
TCR recognition of peptide/MHC class II complexes and superantigens
چکیده انگلیسی

Major histocompatibility complex (MHC) class II molecules display peptides to the T cell receptor (TCR). The ability of the TCR to discriminate foreign from self-peptides presented by MHC molecules is a requirement of an effective adaptive immune response. Dysregulation of this molecular recognition event often leads to a disease state. Recently, a number of structural studies have provided significant insight into several such dysregulated interactions between peptide/MHC complexes and TCR molecules. These include TCR recognition of self-peptides, which results in autoimmune reactions, and of mutant self-peptides, common in the immunosurveillance of tumors, as well as the engagement of TCRs by superantigens, a family of bacterial toxins responsible for toxic shock syndrome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 19, Issue 4, August 2007, Pages 262–271
نویسندگان
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