کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3391722 | 1221074 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Generation of pro-T cells in vitro: potential for immune reconstitution
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Generation of pro-T cells in vitro: potential for immune reconstitution Generation of pro-T cells in vitro: potential for immune reconstitution](/preview/png/3391722.png)
چکیده انگلیسی
Immunodeficient individuals are susceptible to opportunistic infection. While stem cell transplantation can restore a functional immune system, T cells are slow to recover and limited in eliciting adaptive immune responses. Approaches to selectively enhance T cell function have focused on boosting thymopoiesis to generate new T cells or expanding existing T cells. By taking advantage of the role of Notch signaling in T cell development, we have developed an in vitro system able to generate large numbers of progenitor T cells from human hematopoietic stem cells. Here, we discuss this in vitro system and its implications for the potential treatment of T cell immunodeficiency.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 19, Issue 5, October 2007, Pages 341–349
Journal: Seminars in Immunology - Volume 19, Issue 5, October 2007, Pages 341–349
نویسندگان
Génève Awong, Ross N. La Motte-Mohs, Juan Carlos Zúñiga-Pflücker,