کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391748 1221078 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeting the development and effector functions of TH17 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Targeting the development and effector functions of TH17 cells
چکیده انگلیسی

T helper (TH) cells can assume different phenotypes characterized by the secretion of distinct effector molecules. Interferon-γ producing TH1 and IL-4 producing TH2 cells have long been recognized as important mediators of host defense, whereas regulatory T cells are known to suppress T cell responses. Recently, TH17 cells were characterized as a novel CD4+ subset that preferentially produces IL-17, IL-17F, and IL-22 as the signature cytokines. TH17 cells appear to play a critical role in sustaining the inflammatory response and their presence is closely associated with autoimmune disease, which makes them an attractive therapeutic target. In this review, we focus on the mechanisms that regulate the differentiation of naive T cells into TH17 cells and on TH17 effector cytokines, as they represent opportunities for therapeutic intervention.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 19, Issue 6, December 2007, Pages 383–393
نویسندگان
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