کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391755 1221079 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity
چکیده انگلیسی

In order to exploit regulatory T cells in a clinical setting it is desirable to be able to generate such cells by a variety of antigens that elicit unwanted immune responses. This goal has been achieved by targeting antigen to dendritic cells under subimmunogenic conditions which results in the conversion of naïve Foxp3 negative T cells into Foxp3-expressing regulatory T cells that are indistinguishable from what has been referred to as natural Treg. Such cells have the ability to interfere with immunity at early as well as late stages of the immune response during which effector cells have already been formed. This suggests that Treg cannot only be exploited to prevent immune responses but also to interfere with already established immunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 18, Issue 2, April 2006, Pages 89–92
نویسندگان
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