کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3391768 1221080 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preservation of self: An overview of E3 ubiquitin ligases and T cell tolerance
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Preservation of self: An overview of E3 ubiquitin ligases and T cell tolerance
چکیده انگلیسی

Until recently ubiquitination of a protein was thought to simply serve the mundane task of targeting a protein for proteasomal degradation. Accumulating evidence over the past decade has demonstrated the importance of ubiquitination in non-degradative functions including regulating cellular signaling, that highlight its role in human disease and thus potential development of novel therapeutics. Much has been written about ubiquitination in the immune system, in this review we will outline our current knowledge of ubiquitination with respect to T cell tolerance. Specifically, we will provide on overview of E3 ubiquitin ligases and their role in various states of CD4+ T cell tolerance: central and peripheral.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 19, Issue 3, June 2007, Pages 188–196
نویسندگان
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