Sirolimus-based regimen promotes inhibitory costimulatory signal of HVEM/BTLA/CD160/LIGHT pathway in allo-renal recipients

► Sirolimus significantly promoted the expression of both inhibitory costimulators BTLA and CD160 on T cells. ► Sirolimus obviously suppressed the expression of positive costimulator LIGHT on T cells. ► Sirolimus significantly promoted the expression of HVEM on CD4 + Tregs.