Subjective wellbeing under quetiapine treatment: Effect of diagnosis, mood state, and anxiety

ObjectiveTo examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR.Methods2175 patients with schizophrenia-spectrum (SZ, n = 1681), schizoaffective (SA, n = 249), and bipolar disorder (BPD, n = 245) were treated with quetiapine over 6 months and assessed with the Clinical Global Impression-Severity of illness Scale (CGI-S) and the Subjective Wellbeing under Neuroleptic Treatment Scale (SWN-K). Diagnostic group differences and effects of mood state and anxiety on subjective wellbeing were analyzed using multi-factorial linear regression analysis and mixed models repeated measures.ResultsAt baseline, despite similar CGI-S scores, significant SWN-K score differences between SZ (57.7 points), SA (64.1 points), and BPD (79.5 points) were detected. At baseline, depression (p < 0.001) and anxiety (p < 0.001) were independently associated with a worse and mania (p < 0.001) with a better subjective wellbeing. Subjective wellbeing improved significantly in all groups (p < 0.001; 27.6 points), and endpoint subjective wellbeing was not predicted by baseline depression or anxiety, but by endpoint depression and anxiety.ConclusionInterventions to improve subjective wellbeing should take into account the course of mood state and anxiety. Assessment of subjective wellbeing and subjective quality of life in acute mania may need adapted tools.