کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3394231 | 1221454 | 2010 | 6 صفحه PDF | دانلود رایگان |

To investigate the relationship between NF-κB activation and hepatic stellate cell (HSC) apoptosis in hepatosplenic schistosomiasis, hepatic biopsies from patients with Schistosoma mansoni-induced periportal fibrosis, hepatitis C virus-induced cirrhosis, and normal liver were submitted to α-smooth muscle actin (α-SMA) and NF-κB p65 immunohistochemistry, as well as to NF-κB Southwestern histochemistry and TUNEL assay. The numbers of α-SMA-positive cells and NF-κB- and NF-κB p65-positive HSC nuclei were reduced in schistosomal fibrosis relative to liver cirrhosis. In addition, increased HSC NF-κB p65 and TUNEL labeling was observed in schistosomiasis when compared to cirrhosis.These results suggest a possible relationship between the slight activation of the NF-κB complex and the increase of apoptotic HSC number in schistosome-induced fibrosis, taking place to a reduced HSC number in schistosomiasis in relation to liver cirrhosis. Therefore, the NF-κB pathway may constitute an important down-regulatory mechanism in the pathogenesis of human schistosomiasis mansoni, although further studies are needed to refine the understanding of this process.
Journal: Acta Tropica - Volume 113, Issue 1, January 2010, Pages 66–71