کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
339427 548081 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia
چکیده انگلیسی

Matrix metalloproteinase-9 (MMP-9) plays a role in many pathological conditions (e.g. cancer and heart disease). Recently, MMP-9 has been implicated in the activity of the prefrontal cortex and we therefore hypothesized that the MMP-9 gene may be associated with schizophrenia. We genotyped the functional − 1562C/T polymorphism in a group of 442 schizophrenia patients and in 558 healthy control subjects. A significant preponderance of C/C genotype and C allele was found in the schizophrenia subjects compared to healthy controls. The results may provide the first evidence for involvement of the MMP-9 gene in the pathogenesis of schizophrenia and could also contribute to explaining a genetic connection between schizophrenia and some somatic illnesses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 109, Issues 1–3, April 2009, Pages 90–93
نویسندگان
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