کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
339429 548081 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased antibodies for the α7 subunit of the nicotinic receptor in schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Increased antibodies for the α7 subunit of the nicotinic receptor in schizophrenia
چکیده انگلیسی

One of the etiological theories of schizophrenia is dysregulation of the immune system. Autoantibodies specific for the α7 subunit of the nicotinic receptor could potentially contribute to the pathophysiology of the disease. In this study, positive antibodies specific for the receptor were found to exist in 23% of the patients diagnosed with schizophrenia (n = 21). On the average, levels for the antibody were elevated in the schizophrenia patient population than in controls. The data also suggests that there is a significant correlation between antibody titer and age, lending support to the neurodegenerative nature of the disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 109, Issues 1–3, April 2009, Pages 98–101
نویسندگان
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