کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3398404 1222284 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of neutrophils in the development and outcome of zygomycosis in haematological patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
The role of neutrophils in the development and outcome of zygomycosis in haematological patients
چکیده انگلیسی

Zygomycosis constitutes the third leading cause of invasive fungal infections following aspergillosis and candidosis. Patients with haematologic malignancies or haematopoietic stem cell transplantation are particularly susceptible to zygomycosis. Neutropenia represents the most important pathogenic mechanism influencing the onset and outcome of zygomycosis. Neutrophils cause a lesion of the fungal wall with subsequent destruction by macrophages. They also enhance the activity of antifungal drugs against Zygomycetes. Strategies that aim to increase neutrophil count and function, such as granulocyte colony stimulating factor and granulocyte transfusion, could play an important role in the management of this life-threatening infectious complication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 15, Supplement 5, 2009, Pages 33–36
نویسندگان
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