کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3398682 | 1222311 | 2008 | 8 صفحه PDF | دانلود رایگان |

In order to examine secular changes in the incidence and mortality associated with Staphylococcus aureus bacteraemia before and after the emergence of methicillin-resistant S. aureus (MRSA), a retrospective cohort study of 815 patients with S. aureus bacteraemia was performed in the Estrie region of Quebec, Canada, between 1991 and 2005. The primary outcome was all-cause 30-day mortality. Between 1991–1993 and 2003–2005, the proportion of cases attributed to endocarditis and pneumonia increased from 4% to 11% and from 2% to 11%, respectively, while that attributed to catheter infections decreased from 49% to 17%. MRSA was almost absent in 1991–1999, but accounted for 10% and 20% of cases in 2000–2002 and 2003–2005, respectively. The population incidence of bacteraemia caused by methicillin-susceptible S. aureus (MSSA) remained stable between 1997 and 2005, while that of MRSA increased from 0 to 7.4/100 000. Risk-factors for mortality included age, co-morbidities, female gender, residence outside the city of Sherbrooke, pneumonia (OR 3.35, 95% CI 1.96–5.73) or endocarditis (OR 2.89, 95% CI 1.67–5.01) as the source, and an absence of treatment. After adjusting for confounders, patients with MRSA bacteraemia had a higher mortality rate than those with MSSA bacteraemia (OR 2.21, 95% CI 0.99–4.96, p 0.053). Mortality in patients with MSSA bacteraemia was 19% (16/83) in 1991–1993, 23% (26/113) in 1994–1996, 29% (50/173) in 1997–1999, and 28% (52/185) in 2000–2002, decreasing to 15% (28/192) in 2003–2005, which impacted on the relative mortality rates of MRSA and MSSA. MRSA did not replace, but added to, an existing stable incidence of MSSA bacteraemia.
Journal: Clinical Microbiology and Infection - Volume 14, Issue 5, May 2008, Pages 421–428