کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3398933 1222349 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or lopinavir–ritonavir with a backbone of two nucleoside reverse transcriptase inhibitors
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Efficacy and safety of an anti-retroviral combination regimen including either efavirenz or lopinavir–ritonavir with a backbone of two nucleoside reverse transcriptase inhibitors
چکیده انگلیسی

ABSTRACTThe efficacy and safety of a combination regimen including either efavirenz or lopinavir–ritonavir was examined in a cohort of 65 patients positive for human immunodeficiency virus-1 (HIV-1). Both the efavirenz (n = 33, 18 anti-retroviral naive) and lopinavir–ritonavir (n = 32, 15 naive) regimens achieved significant changes from baseline CD4 cell counts and HIV RNA levels after 108 weeks (p < 0.01). Despite diminished immunological and virological parameters at study entry, the lopinavir– ritonavir group showed greater virological effects than the efavirenz group after 108 weeks (median change 3.3 log10, interquartile range (IQR) 2.2–3.8 log10 vs. 2.4 log10, IQR 0.9–3.3 log10, respectively, p 0.004). Use of lopinavir–ritonavir, in contrast to use of efavirenz, was associated with significant hypertriglyceridaemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 12, Issue 5, May 2006, Pages 486–489
نویسندگان
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