کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
339942 | 548536 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
COMT gene is a logical candidate gene for schizophrenia. Moreover, variations in the COMT Val158Met functional polymorphism have been associated with prefrontal cognitive abnormalities among patients with schizophrenia, healthy relatives and controls. In this study, using an epidemiologically-based sample of 130 patients experiencing a first-episode of a non-affective psychosis, we examined whether COMT Val158Met genotype influenced cognitive performance on the phenotypic expression of psychosis. We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 102, Issues 1–3, July 2008, Pages 206–209
Journal: Schizophrenia Research - Volume 102, Issues 1–3, July 2008, Pages 206–209
نویسندگان
Ignacio Mata, Rocio Perez-Iglesias, Jose Maria Pelayo-Teran, Jose Manuel Rodríguez-Sanchez, Cesar Gonzalez-Blanch, Eugenio Carrasco-Marin, Jose Luis Vazquez-Barquero, Benedicto Crespo-Facorro,