کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
340028 548181 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No association between the DRD3 Ser9Gly polymorphism and schizophrenia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
No association between the DRD3 Ser9Gly polymorphism and schizophrenia
چکیده انگلیسی

ObjectiveTo investigate the association between a Ser9Gly polymorphism of the dopamine D3 receptor gene (DRD3) and schizophrenia.Methods408 schizophrenic patients and 172 control subjects were compared with regard to their DRD3 Ser9Gly genotypic and allelic frequencies. In addition, we carried out a family-based association study including 183 pedigrees (472 subjects) using the transmission disequilibrium test (TDT).ResultsNo significant differences of genotype or homozygosity distribution were identified between patients and controls. When patients were stratified according to gender, response to treatment, age at onset, no significant differences were observed. Neither allele A (Ser), or G (Gly) were preferentially transmitted from parents to affected offspring.ConclusionThe hypothesis that the DRD3 Ser9Gly polymorphism plays a predisposing role in schizophrenia is not supported by this study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 98, Issues 1–3, January 2008, Pages 98–104
نویسندگان
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