کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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340124 | 548191 | 2007 | 11 صفحه PDF | دانلود رایگان |

BackgroundNicotine dependence is common in schizophrenia patients but rare in patients with obsessive–compulsive disorder. Little is known, however, about smoking in schizophrenia patients with obsessive–compulsive symptoms (OCS) especially in a developing country, such as Egypt, that has the highest rate of tobacco consumption in the Middle East and North Africa.ObjectivesTo test a hypothesis that nicotine dependence in schizophrenia patients with-OCS is lower than in those without-OCS.ResultsOut of 87 consecutive schizophrenia patients attending a psychiatric out-patients clinic in Egypt, 34 patients (39%) had significant OCS, and a smoking rate (85.3%) not significantly lower than that of patients without-OCS (90.6%). Patients were reclassified by their Fagerström's scores into 3 groups of nicotine dependence: mild (37 patients), high (21 patients) and very high (29 patients). There were no differences between these groups in terms of YBOCS scores (F = 0.324; p = 0.724). When comparing PANSS scores of patients, with and without-OCS, those of the former group were higher on the positive symptoms (mean = 24.2 versus 20.8; p = 0.002), and anxiety/depression (mean = 10.8 versus 10.1; p = 0.03) but lower on the negative symptoms (mean = 15.0 versus 19.4; p = 0.000), disorganized thoughts (mean = 14.5 versus 17.5; p = 0.002), and uncontrolled hostility/excitement) (mean = 7.5 versus 9.5; p = 0.002). However, there was no significant between-group difference in the total PANSS scores.ConclusionsThe high and equal rates of smoking in patients with-, and without-OCS, and the lack of difference between YBOCS scores of mild, high and very high nicotine dependence groups undermined our initial hypothesis that nicotine dependence in schizophrenia patients with-OCS is lower than in those without them. Nevertheless, the finding of a distinctive PANSS scores, may support a suggestion that OCS in schizophrenia represent a distinct subtype or dimension.
Journal: Schizophrenia Research - Volume 95, Issues 1–3, September 2007, Pages 236–246