کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
340177 548203 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced anterior internal capsule and thalamic volumes in first-episode psychosis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Reduced anterior internal capsule and thalamic volumes in first-episode psychosis
چکیده انگلیسی

BackgroundThe thalamus is the gateway for sensory and motor information en route to the cortex. Information is processed via thalamocortical and corticothalamic pathways coursing through the internal capsules. In this study, we investigated the relationship between the anterior limb of the internal capsule, posterior limb of the internal capsule, and thalamus in first-episode psychosis (FEP).MethodsTwenty-nine FEP subjects (26 DSM-IV schizophrenia, 2 schizoaffective disorder, 1 psychosis not otherwise specified) and 22 healthy volunteers participated in this study. Anterior limb of the internal capsule (AIC), posterior limb of the internal capsule (PIC), and the thalamus volumes were manually determined from MRI scans.ResultsFEP subjects had reduced AIC volumes (F(1,45) = 6.18, p = 0.017) and thalamic volumes (F(1,45) = 8.00, p = 0.007) compared to healthy volunteers. PIC volumes did not differ. Significant correlations between AIC volumes and thalamic volumes were observed in subjects with FEP, but not in healthy volunteers. Negative relationships between thalamic volumes and symptom severity were also observed.ConclusionsThe AIC and thalamic volumes were reduced in subjects with FEP compared to healthy volunteers. Abnormalities in thalamocortical and orticothalamic pathways may contribute to functional disruption of neural circuits in psychosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Schizophrenia Research - Volume 87, Issues 1–3, October 2006, Pages 89–99
نویسندگان
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