کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3407714 1223638 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural and biological properties of Cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Structural and biological properties of Cucumber mosaic virus particles carrying hepatitis C virus-derived epitopes
چکیده انگلیسی

The Cucumber mosaic virus (CMV) is a three-component isodiametric plant virus with an extremely wide host range, present worldwide. A pseudorecombinant form has been described, deriving from the RNA3 component of the CMV-S strain, carrying the coat protein (CP) gene, and the RNA 1, 2 components of the CMV-D strain. The CP gene was then engineered to express one or two copies of a synthetic peptide derived from many hypervariable region 1 (HVR1) sequences of the Hepatitis C virus (HCV) envelope protein E2 (the so-called R9 mimotope).Study of the symptoms pattern displayed in tobacco by these chimeric CMV particles, together with determination of their structural characteristics, assessed by circular dichroism (CD) spectroscopy and electron microscopy, revealed a possible relationship between the biological behavior and the structural properties of virus components.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Virological Methods - Volume 155, Issue 2, February 2009, Pages 118–121
نویسندگان
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