کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3408445 1223664 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
پیش نمایش صفحه اول مقاله
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3
چکیده انگلیسی

The objective of this study was to investigate whether the anti-retroviral cellular cytidine deaminase, APOBEC3, inhibits the infectivity of human T cell leukemia virus type I (HTLV-I). Sufficient quantities of cell-free HTLV-I virion for infection were obtained by cotransfecting cells with HTLV-I and human or murine APOBEC3 expression vectors along with a plasmid expressing Tax. HTLV-I viruses containing these deaminases were still capable of infecting 293T and MOLT-4 cells. No G-to-A mutations, which are characteristic of cytidine deaminases, were observed in the HTLV-I genome. These results suggest that the enzymatic activity of APOBEC3 may not contribute substantially to antiviral responses to HTLV-I.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Virological Methods - Volume 139, Issue 1, January 2007, Pages 93–96
نویسندگان
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