کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
340899 548388 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Open prospective study on oxcarbazepine in epilepsy in children: A preliminary report
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Open prospective study on oxcarbazepine in epilepsy in children: A preliminary report
چکیده انگلیسی

SummaryPurposeTo evaluate the long-term efficacy, tolerability, and safety of oxcarbazepine (OXC) in children with epilepsy.MethodsWe enrolled 36 patients (median age 7.75) with new diagnosis of partial epilepsy in an open prospective study. All type of epilepsy were included: 25 patients were affected by idiopathic epilepsy, eight by symptomatic epilepsy and three by cryptogenic epilepsy. Patients were then scheduled to come back for controls at 3 months (T1), 12 months (T2) and 24 months (T3) after the beginning of OXC-monotherapy (T0). At each control we evaluated patients through their seizure diary, a questionnaire on side effects, their level of 10-monohydroxy (MHD) metabolite and laboratory analysis.ResultsAt T1, 21/36 patients (58.3%) were seizure-free, 3/36 patients (8.3%) showed an improvement higher than 50%, 3/36 (8.3%) lower than 50%, while 2/36 worsened (5.6%). In 7/36 (19.5%) patients, no improvement was reported. At T2 13/18 patients (72.2%) were seizure-free, 1/18 showed a response to therapy higher than 50% while 2/18 worsened (11%). In two patients no improvement was reported. A correspondence between MHD plasmatic levels and clinical response (r = 0.49; p < 0.05) was only registered at T1.An EEG normalization was observed in 25% of cases. Side effects were reported in 25% of cases, but symptoms progressively disappeared at follow-up.ConclusionsWe can therefore conclude that OXC can be considered, for its efficacy and safety, as a first line drug in children with epilepsy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 15, Issue 5, July 2006, Pages 292–298
نویسندگان
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