کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
340996 548414 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Abnormal motor cortex plasticity in juvenile myoclonic epilepsy
ترجمه فارسی عنوان
پوسیدگی قشر حرکتی غیر طبیعی در صرع مایوکلونیک نوجوانان
کلمات کلیدی
صرع مایوکلونیک نوجوانان، تحریک مغناطیسی ترانس مغناطیسی، تحریک وابسته به انگشتی، پلاستیک سیناپتیس
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• The pathophysiology of juvenile myoclonic epilepsy (JME) is somewhat obscure.
• Paired associative stimulation (PAS) induces LTP-like plasticity in motor cortex.
• The response to PAS is defective in patients with JME.
• Defective motor cortex plasticity is likely involved in the pathogenesis of JME.

PurposeAbnormal cortical plasticity has been hypothesized to play a crucial role in the pathogenesis of juvenile myoclonic epilepsy (JME). To study the motor cortical plasticity we used paired associative stimulation (PAS). When a repetitive electrical stimulus to the median nerve is paired with a transcranial magnetic stimulus (TMS) pulse over the controlateral motor cortex with at an interstimulus interval (ISI) of 21.5–25 ms, a long term potentiation (LTP)-like synaptic plasticity is induced in the corticospinal system.Aim of this study was to investigate the motor cortex LTP-like synaptic plasticity by means of PAS in patients with JME.MethodsTwelve adult patients with JME were compared with 13 healthy subjects of similar age and sex. PAS consisted of 180 electrical stimuli of the right median nerve paired with a single TMS over the hotspot of right abductor pollicis brevis (APB) at an ISI of 25 ms (PAS25). We measured motor evoked potentials (MEPs) before and after each intervention for up to 30 min.ResultsIn healthy subjects the PAS25 protocol was followed by a significant increase of the MEP amplitude (p < 0.001). On the contrary, in patients with JME, the MEP amplitude did not change.ConclusionDefective motor cortex plasticity is likely involved in the pathogenesis of JME.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 30, August 2015, Pages 101–105
نویسندگان
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