کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
341280 548488 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiepileptic drugs and liver disease
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Antiepileptic drugs and liver disease
چکیده انگلیسی

SummaryAntiepileptic drugs (AEDs) are no longer restricted to the treatment of epilepsy. These are widely used in a broad spectrum of psychiatric and neurological disorders. Liver plays a major role in the metabolism of a majority of these drugs. Hepatotoxicity is rare, but a real concern when initiating therapy. Likewise, liver disease can adversely affect the biotransformation of some of these drugs.This manuscript addresses the significance of elevated liver enzymes associated with AED use, the role of therapeutic drug monitoring, pharmacokinetics during liver disease and potential risk of hepatotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 15, Issue 3, April 2006, Pages 156–164
نویسندگان
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