کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3415216 1224947 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antibody profiling in plague patients by protein microarray
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Antibody profiling in plague patients by protein microarray
چکیده انگلیسی

A protein microarray containing 144 known or putative virulence-related proteins of Yersinia pestis was used to evaluate the antibody responses of plague patients. Forty-two proteins were found to be expressed in vivo and antibodies against 14 of them were detected in all patients analyzed, providing potential candidates for novel protective antigens and novel serodiagnostic markers in Y. pestis. Moreover, the lack of antibody to LcrV in the five patients in Focus F might be a challenge to our understanding of the pathogenesis of Y. pestis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 10, Issue 1, January 2008, Pages 45–51
نویسندگان
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