کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3415273 1224951 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity
چکیده انگلیسی

We examined various HIV-1 Vif mutants for interaction with APOBEC3 proteins (A3G/A3F). All replication-defective proviral mutants were found to carry A3G/A3F in virions, and of these, a replication-defective mutant with Vif that binds to A3G in cells but not in virions was noted. Furthermore, a mutant Vif protein that suppresses A3F activity but does not exclude A3F from virions was identified. We also showed that incorporation of Vif into virions is dependent on its interaction with A3G/A3F. Taken together, we concluded that functional binding of Vif to A3G/A3F in cells and/or virions is critical for viral infectivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 12, Issue 2, February 2010, Pages 166–171
نویسندگان
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