کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3415353 1224956 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The alternative sigma factor sigma B of Staphylococcus aureus modulates virulence in experimental central venous catheter-related infections
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The alternative sigma factor sigma B of Staphylococcus aureus modulates virulence in experimental central venous catheter-related infections
چکیده انگلیسی

The impact of the alternative sigma factor sigma B (SigB) on pathogenesis of Staphylococcus aureus is not conclusively clarified. In this study, a central venous catheter (CVC) related model of multiorgan infection was used to investigate the role of SigB for the pathogenesis of S. aureus infections and biofilm formation in vivo. Analysis of two SigB-positive wild-type strains and their isogenic mutants revealed uniformly that the wild-type was significantly more virulent than the SigB-deficient mutant. The observed difference in virulence was apparently not linked to the capability of the strains to form biofilms in vivo since wild-type and mutant strains were able to produce biofilm layers inside of the catheter. The data strongly indicate that the alternative sigma factor SigB plays a role in CVC-associated infections caused by S. aureus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 10, Issue 3, March 2008, Pages 217–223
نویسندگان
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