کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415754 | 1224977 | 2007 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis](/preview/png/3415754.png)
Cytokines are increasingly recognized as important components of the cellular immune responses to intracellular pathogens. In this study, we analyzed the production of TGF-β, IL-10 and IFN-γ by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.). We demonstrated that IFN-γ is produced in controls and LCL patients, IL-10 only in LCL patients and TGF-β only in naïve subjects. Furthermore, in naive subjects, neutralization of TGF-β induced IL-10 production. IL-10 produced in naïve subjects when TGF-β is neutralized or in LCL patients did not modify the IFN-γ production but inhibit reactive nitrogen species production. Analysis of the phenotype of IL-10 producing cells in naive subjects when TGF-β is neutralized clearly showed that they are memory CD45RA− CD8+ T cells. In LCL patients, IL-10 producing cells are both CD45RA− CD4 and CD8+ T cells. The role of these IL-10 producing CD8+ T cells in the development of the diseases should be carefully evaluated.
Journal: Microbes and Infection - Volume 9, Issue 8, July 2007, Pages 1034–1041