کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415785 | 1224980 | 2008 | 5 صفحه PDF | دانلود رایگان |
Dendritic cells were discovered 25 years ago as professional antigen presenting cells bridging together innate and adaptive immunity. Recently additional functions of dendritic cells have been uncovered indicating a relevant role of dendritic cells in immune system regulation. Indeed, they are the professional sensors of the immune system that can detect perturbations caused by non-self infectious as well as self non-infectious signals in most tissues. Dendritic cells discriminate both antigen amounts and antigen persistence through their receptor repertoire via the integration of different signaling pathways. The environment plays an essential role in conditioning the effector functions of dendritic cells leading either to the activation or suppression of adaptive immunity.
Journal: Microbes and Infection - Volume 10, Issue 9, July 2008, Pages 990–994