کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3415794 1224980 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis?
چکیده انگلیسی

Respiratory pathogens are amongst the world's most successful killers. Tuberculosis kills approximately 2 million individuals each year, and pertussis is responsible for roughly 300,000 annual deaths. Although the two diseases are fundamentally different in the expression of their pathogenesis and in the biology of their causative agents, a common heterologous prime/boost vaccination strategy is proposed, using live attenuated vaccines against tuberculosis (the already existing BCG) and pertussis (a novel attenuated Bordetella pertussis strain) early in life for priming, followed by a booster with acellular vaccines, based on the novel heparin-binding haemagglutinin for tuberculosis, and already available acellular vaccines against pertussis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 10, Issue 9, July 2008, Pages 1051–1056
نویسندگان
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