کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3415998 | 1224986 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice Interleukin-18 enhances a Th2 biased response and susceptibility to Leishmania mexicana in BALB/c mice](/preview/png/3415998.png)
چکیده انگلیسی
Interleukin-18 deficient mice on a BALB/c background display increased resistance to cutaneous infection with Leishmania mexicana, with reduced lesion progression and reduced parasite burdens compared with wild-type mice. Infected IL-18−/− mice had lower antigen specific IgG1 levels and total IgE levels and conversely higher antigen specific IgG2a levels than similarly infected wild-type mice. Splenocytes isolated from infected IL-18−/− mice produced significantly lower levels of antigen induced IL-4 and higher levels of IFN-γ than wild-type animals. Consequently IL-18 during L. mexicana infection of BALB/c mice promotes a Th2 biased response and thereby has a disease exacerbating role.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 10, Issue 7, June 2008, Pages 834–839
Journal: Microbes and Infection - Volume 10, Issue 7, June 2008, Pages 834–839
نویسندگان
Karen Jane Bryson, Xiao-Qing Wei, James Alexander,