کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3416255 1593694 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Synthesis of N-substituted phthalimides and their antifungal activity against Alternaria solani and Botrytis cinerea
چکیده انگلیسی


• Non-sulfur and non-phosphorus phthalimides were synthesized.
• Their antifungal activity was evaluated.
• The efficacious compounds were discovered.
• The structure-activity relationships provided meaningful guidance for preparing phthalimides related fungicides.

As organosulfur and organophosphorus agents, phaltane and phosmet are facing great challenges for the environmental contamination, mammalian toxicity and increasing resistance with long term use. It is efficient and meaningful to develop phthalimide-based alternatives with non-sulfur and non-phosphorus groups. A series of N-substituted phthalimides were synthesized and their antifungal activity against two disastrous phytopathogenic fungi, Alternaria solani and Botrytis cinerea was evaluated in vitro. Most of them showed significant antifungal activity against both of fungi, or either of them selectively. N-vinylphthalimide (4) and 8-[4-(phthalimide-2-yl) butyloxy] quinoline (13) were identified as the most promising candidates against B. cinerea and A. solani with the IC50 values of 7.92 μg/mL and 10.85 μg/mL respectively. The brief structure-activity relationships have revealed that vinyl, quinolyl, bromide alkyl and benzyl substitutions were appropriate substituents and coupling functional moieties indirectly with optimum alkyl chain was efficient to prepare phthalimides related fungicides.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 95, June 2016, Pages 186–192
نویسندگان
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