کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3416412 1593699 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells
چکیده انگلیسی

Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-κB pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 90, January 2016, Pages 50–54
نویسندگان
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