کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3417775 1225471 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationship between pathological findings and enzymes of the energy metabolism in liver of rats infected by Trypanosoma evansi
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Relationship between pathological findings and enzymes of the energy metabolism in liver of rats infected by Trypanosoma evansi
چکیده انگلیسی


• T. evansi infection alters some important parameters of the energy metabolism in rat liver.
• Changes in adenylate kinase and pyruvate kinase lead to liver injury.
• Infected animals with T. evansi presented decrease of Na+, K+ ATPase activity.
• Decreases in energy production may be implicated in the pathophysiology of the disease.

The aim of this study was to investigate the activities of important enzymes involved in the energetic metabolism in the liver of rats experimentally infected by Trypanosoma evansi. Adenylate kinase (AK), pyruvate kinase (PK), and lactate dehydrogenase (LDH) in liver homogenate, as well as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and clotting time in plasma were evaluated at 5 and 15 days post-infection (PI). The activities of the respiratory chain complexes and of Na+, K+-ATPase were also evaluated. This study demonstrates energetic metabolism impairment in rats infected by T. evansi. A reduced energy metabolism in the liver of rats infected by T. evansi was observed, demonstrated by AK decreased and PK increased activities at 5 days PI, a mechanism known as energetic compensation. However, at 15 days PI a decrease of AK and PK activities were observed. In addition, an increase in the activities of respiratory chain complexes II, II–III and IV in infected rats at 15 days PI, and a decrease of Na+, K+-ATPase activities in infected rats on days 5 and 15 PI were verified. In the plasma, we observed an increase in ALT and AST activities on days 5 and 15 PI, and increase in clotting time in infected rats. The changes caused by T. evansi infection on the activity of enzymes of hepatic energy metabolism can corroborate to elucidate the mechanisms that lead to liver injury and inflammatory infiltration verified in T. evansi infected rats. Therefore, these alterations are directly related to disease pathogenesis.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Parasitology International - Volume 64, Issue 6, December 2015, Pages 547–552
نویسندگان
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