کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3421167 1594043 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mass treatment with albendazole reduces the prevalence and severity of Oesophagostomum-induced nodular pathology in northern Ghana
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Mass treatment with albendazole reduces the prevalence and severity of Oesophagostomum-induced nodular pathology in northern Ghana
چکیده انگلیسی
Previous surveys conducted in northern Ghana where Oesophagostomum bifurcum is endemic showed that O. bifurcum-induced nodular pathology could be detected in up to 50% of the inhabitants. The impact of albendazole-based mass treatment to control both infection and morbidity is assessed and compared with the situation in a control area where no mass treatment has taken place. A significant reduction in the prevalence of infection based on stool cultures was achieved following two rounds of mass treatment in one year: from 52.6% (361/686) pre treatment to 5.2% (22/421) 1 year later (χ12=210.1; P < 0.001). At the same time, the morbidity marker of ultrasound-detectable nodules declined from 38.2% to 6.2% (χ12=138.1; P < 0.001). There was a shift from multinodular pathology, often seen in heavy infections, to uninodular lesions. In the control villages where no treatment took place, O. bifurcum infection increased from 17.8% (43/242) to 32.2% (39/121) (χ12=9.6; P < 0.001). Nodular pathology decreased slightly from 21.5% to 19.0%, but a higher proportion of these subjects developed multinodular pathology compared with baseline (χ12=5.5; P = 0.019). It is concluded that repeated albendazole treatment significantly reduces O. bifurcum-induced morbidity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 100, Issue 8, August 2006, Pages 760-766
نویسندگان
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