کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3421167 | 1594043 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mass treatment with albendazole reduces the prevalence and severity of Oesophagostomum-induced nodular pathology in northern Ghana
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
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چکیده انگلیسی
Previous surveys conducted in northern Ghana where Oesophagostomum bifurcum is endemic showed that O. bifurcum-induced nodular pathology could be detected in up to 50% of the inhabitants. The impact of albendazole-based mass treatment to control both infection and morbidity is assessed and compared with the situation in a control area where no mass treatment has taken place. A significant reduction in the prevalence of infection based on stool cultures was achieved following two rounds of mass treatment in one year: from 52.6% (361/686) pre treatment to 5.2% (22/421) 1 year later (Ï12=210.1; PÂ <Â 0.001). At the same time, the morbidity marker of ultrasound-detectable nodules declined from 38.2% to 6.2% (Ï12=138.1; PÂ <Â 0.001). There was a shift from multinodular pathology, often seen in heavy infections, to uninodular lesions. In the control villages where no treatment took place, O. bifurcum infection increased from 17.8% (43/242) to 32.2% (39/121) (Ï12=9.6; PÂ <Â 0.001). Nodular pathology decreased slightly from 21.5% to 19.0%, but a higher proportion of these subjects developed multinodular pathology compared with baseline (Ï12=5.5; PÂ =Â 0.019). It is concluded that repeated albendazole treatment significantly reduces O. bifurcum-induced morbidity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 100, Issue 8, August 2006, Pages 760-766
Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene - Volume 100, Issue 8, August 2006, Pages 760-766
نویسندگان
J.B. Ziem, N. Spannbrucker, A. Olsen, P. Magnussen, B.M.W. Diederen, J. Horton, A.M. Polderman,